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Each person is Neanderthal

27 May 2014 [15:45] - TODAY.AZ
We have met Neanderthals, and they are us – or about 1 to 4 percent of each of us.

That is one implication of a four-year effort to sequence the Neanderthal genome – essentially setting out in order some 3 billion combinations of four key molecules that together represent the Neanderthals' genetic blueprint.

So far, the international team reporting the results notes that they've sequenced 60 percent of the Neanderthal genome. And the 60 percent they have – essentially a rough draft – is likely to be rife with errors that will emerge and get corrected over time.

Still, the results mark "just the beginning of an exploration of human uniqueness that it now possible" as anthropologists move beyond fossils to genes in uncovering the story of human evolution, says Svante Pääbo, who heads the Neanderthal Genome Project at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Among the tale the genes tell: A few anatomically modern humans mated with Neanderthals, likely in North Africa or the Middle East as modern humans initially were moving out of Africa, the researchers say.

The team came to that conclusion after comparing the Neanderthal genome with those of five humans today: one each from Europe, Asia, and Papua New Guinea, and two from different regions of sub-Saharan Africa. They found that from 1 to 4 percent of the DNA in the genomes of people from Eurasia and the southwestern Pacific were inherited from Neanderthals. Neanderthal-derived genes failed to show up in the African genomes.

The results overturn what Dr. Pääbo calls the "hard out-of-Africa hypothesis" in which a small group of anatomically modern humans migrates from Africa "and replaced everyone else in the world without any admixture." It's entirely possible that African genomes also contain some other form of what Pääbo dubs "caveman biology" from more archaic hominins. "We just don't know that yet," he says.

Nor is it clear yet whether the presence of this DNA in modern humans represents positive selection – genetic material worth holding on to – or biological antiques whose functions have long been lost, the researchers say. So far, the inherited material does not seem to be concentrated in genes, but spread somewhat randomly in non-gene portions of the modern-human genomes.



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